Protein kinase C signaling dysfunction in von Willebrand disease (p.V1316M) type 2B platelets
Résumé
Key Points In VWD (p.V1316M) type 2B, the VWF–GPIb interaction alters the sustained PKC-mediated pathway of Rap1 activation. VWF/p.V1316M expression in mice causes multiple platelet dysfunctions, including significant ADAM17-independent shedding of GPIbα.
Domaines
Sciences du Vivant [q-bio]Origine | Fichiers produits par l'(les) auteur(s) |
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