Comparative effects of well-balanced diets enriched in alpha-linolenic or linoleic acids on LC-PUFA metabolism in rat tissues - Institut Agro Rennes-Angers Accéder directement au contenu
Article Dans Une Revue Prostaglandins, Leukotrienes and Essential Fatty Acids Année : 2013

Comparative effects of well-balanced diets enriched in alpha-linolenic or linoleic acids on LC-PUFA metabolism in rat tissues

Résumé

The intake of the essential fatty acid precursor alpha-linolenic acid (ALA) contributes to ensure adequate n-3 long-chain polyunsaturated fatty acid (LC-PUFA) bioavailability. Conversely, linoleic acid (LA) intake may compromise tissue n-3 PUFA status as its conversion to n-6 LC-PUFA shares a common enzymatic pathway with the n-3 family. This study aimed to measure dietary ALA and LA contribution to LC-PUFA biosynthesis and tissue composition. Rats were fed with control or experimental diets moderately enriched in ALA or LA for 8 weeks. Liver Delta 6- and Delta 5-desaturases were analyzed and FA composition was determined in tissues (red blood cells, liver, brain and heart). Hepatic Delta 6-desaturase activity was activated with both diets, and Delta 5-desaturase activity only with the ALA diet. The ALA diet led to higher n-3 LC-PUFA composition, including DHA in brain and heart. The LA diet reduced n-3 content in blood, liver and heart, without impacting n-6 LC-PUFA composition. At levels relevant with human nutrition, increasing dietary ALA and reducing LA intake were both beneficial in increasing n-3 LC-PUFA bioavailability in tissues. (c) 2013 Elsevier Ltd. All rights reserved.
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Dates et versions

hal-01210286 , version 1 (02-10-2015)

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H. Blanchard, Frédérique F. Pédrono, Nathalie N. Boulier-Monthéan, Daniel D. Catheline, Vincent V. Rioux, et al.. Comparative effects of well-balanced diets enriched in alpha-linolenic or linoleic acids on LC-PUFA metabolism in rat tissues. Prostaglandins, Leukotrienes and Essential Fatty Acids, 2013, 88 (5), pp.383 - 389. ⟨10.1016/j.plefa.2013.03.006⟩. ⟨hal-01210286⟩
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