Fatty Acid Desaturase 3 (FADS3) Is a Specific ∆13-Desaturase of Ruminant <b><i>trans</i></b>-Vaccenic Acid - Institut Agro Rennes-Angers Accéder directement au contenu
Article Dans Une Revue Lifestyle Genomics Année : 2019

Fatty Acid Desaturase 3 (FADS3) Is a Specific ∆13-Desaturase of Ruminant trans-Vaccenic Acid

Résumé

In mammalian species, the Fatty Acid Desaturase (FADS) gene cluster includes FADS1 (∆5-desaturase), FADS2 (∆6-desaturase), and a third gene member, named FADS3. According to its high degree of nucleotide sequence homology with both FADS1and FADS2, FADS3 was promptly suspected by researchers in the field to code for a new mammalian membrane-bound fatty acid desaturase. However, no catalytic activity was attributed to the FADS3 protein for a decade, until the rat FADS3 protein was shown in vitro to be able to catalyze the unexpected ∆13-desaturation of trans-vaccenic acid, producing the trans11,cis13-conjugated linoleic acid isomer. This review summarizes the recent investigations establishing the FADS3 enzyme as a reliable mammalian trans-vaccenate ∆13-desaturase in vivo and tries to identify further unresolved issues that need to be addressed.

Dates et versions

hal-02290477 , version 1 (17-09-2019)

Identifiants

Citer

Vincent V. Rioux, Philippe Legrand. Fatty Acid Desaturase 3 (FADS3) Is a Specific ∆13-Desaturase of Ruminant trans-Vaccenic Acid. Lifestyle Genomics, 2019, pp.1-7. ⟨10.1159/000502356⟩. ⟨hal-02290477⟩
77 Consultations
0 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More