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Communication Dans Un Congrès Année : 2011

AnnotQTL: a new tool to gather functional and comparative information on a genomic region

Résumé

AnnotQTL is a web tool designed to aggregate functional annotations from different prominent websites by minimizing the redundancy of information. Although thousands of QTL regions have been identified in livestock species, most of them are large and contain many genes. This tool was therefore designed to assist the characterization of genes in a QTL interval region as a step towards selecting the best candidate genes. It localizes the gene to a specific region (using NCBI and Ensembl data) and adds the functional annotations available from other databases (Gene Ontology, Mammalian Phenotype, HGNC and Pubmed). Both human genome and mouse genome can be aligned with the studied region to detect synteny and segment conservation, which is useful for running inter-species comparisons of QTL locations. Finally, custom marker lists can be included in the results display to select the genes that are closest to your most significant markers. We use examples to demonstrate that in just a couple of hours, AnnotQTL is able to identify all the genes located in regions identified by a full genome scan, with some highlighted based on both location and function, thus considerably increasing the chances of finding good candidate genes. AnnotQTL is available at http://annotqtl.genouest.org.

Mots clés

QTL
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Dates et versions

hal-02746678 , version 1 (03-06-2020)

Identifiants

  • HAL Id : hal-02746678 , version 1
  • PRODINRA : 179326

Citer

Frédéric Lecerf, Anthony Bretaudeau, Olivier Sallou, Colette Désert, Anne Blum, et al.. AnnotQTL: a new tool to gather functional and comparative information on a genomic region. 15th QTLMAS, Institut National de Recherche Agronomique (INRA). UMR Génétique Animale (0598)., May 2011, Rennes, France. ⟨hal-02746678⟩
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